
当干细胞老化时,其细胞形态会从细长的纺锤形
变为大而扁平的形状, 同时生长因子, 细胞黏附因子
和抗炎因子等的分泌能力下降, 导致免疫调节能力减弱
It has been proven that with the senescence of hUC-MSCs, the morphology of the cells
changes from elongated fusiform to large and flat (Fig. 4), and the ability of secreting
factors also decreases with senescence, such as growth factors, cell adhesion and
anti-inflammatory factors, manifested as decreased immunomodulatory capacity.